Hypersensitivity to sulphasalazine. Closely monitor patients w/ chronic lung function, especially asthma. Not to be reintroduced treatment in conditions predisposing to myo- or pericarditis development & if acute intolerance syndrome is suspected. Discontinue treatment if blood dyscrasia is suspected. Delayed onset of action in organic or functional obstruction in upper GIT. May lead to false elevated results when measuring urinary normetanephrine by liqd chromatography w/ electrochemical detection. Perform haematological investigations if patient develops unexplained bleeding, bruising, purpura, anaemia, fever or sore throat. Ensure adequate fluid intake during treatment. Evaluate renal function prior to initiation of, & at least twice yrly during treatment. Hepatic impairment. Mild to moderate renal impairment. Pregnancy & lactation. Not recommended in childn <18 yr.
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